Cognitive validation of cross-diagnostic cognitive subgroups on the schizophrenia-bipolar spectrum

JA Karantonis; SL Rossell; SP Carruthers; P Sumner; M Hughes; MJ Green; C Pantelis; KE Burdick; V Cropley; TE Van Rheenen

Journal article

Cognitive validation of cross-diagnostic cognitive subgroups on the schizophrenia-bipolar spectrum

JA Karantonis, SL Rossell, SP Carruthers, P Sumner, M Hughes, MJ Green, C Pantelis, KE Burdick, V Cropley, TE Van Rheenen

Journal of Affective Disorders | ELSEVIER | Published : 2020

DOI: 10.1016/j.jad.2020.01.123

Abstract

Background: Cognitive heterogeneity in schizophrenia spectrum disorders (SSD) and bipolar disorder (BD) has been explored using clustering analyses. However, the resulting subgroups have not been cognitively validated beyond measures used as clustering variables themselves. We compared the emergent cross-diagnostic subgroups of SSD and BD patients on measures used to classify them, and also across a range of alternative cognitive measures assessing some of the same constructs. Method: Domain scores from the Matrics Consensus Cognitive Battery were used in a cross-diagnostic clustering analysis of 86 patients with SSD (n = 45) and BD (n = 41). The emergent subgroups were then compared to each..

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University of Melbourne Researchers

Christos Pantelis Author

Vanessa Cropley Author

Tamsyn van Rheenen Author

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Grants

Awarded by Rockefeller Foundation

Funding Acknowledgements

Financial support from the National Health and Medical Research Council (NHMRC) provided salary support to TVR (Early Career Fellowship 1088785), SR (Senior Research Fellowship 1154651) and CP (Senior Principal Research Fellowships 628386 and 1105825); and Swinburne University/the Australian Government provided postgraduate scholarships to JK, SC and PS. MG was a resident at the Bellagio Center, funded by the Rockefeller Foundation during the production of this manuscript. The authors would also like to acknowledge project specific financial support of the NHMRC (1060664), Henry Freeman Trust, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L Cooper Foundation and the Society of Mental Health Research. Finally, the authors would like to thank the participants in this study for their time and contribution.